What is Tretiva Soft Capsule?

Tretiva is an orally administered Retinoid that is given to treat patients with severe acne that have not shown any response to any other treatment method or therapy. The active drug contained in it is isotretinoin which is also called 13 Cis retinoic acid. The commonly occurring forms of severe acne are nodular acne and cystic acne. 

They cause big, deep, and painful cysts or nodules on the skin. These forms of acne can occur independently altogether which condition is called nodulocystic acne. Severe acne is very difficult to treat and it can even leave scars if it is left untreated.

How Does Tretiva Soft Capsule Treat Acne?

The drug Isotretinoin reduces the oil secreted by the pores present in the skin. It does not have any antimicrobial action of its own. However, since the oil production is decreased, this will prevent the development of clogged pores and prevent the colonization of the sebum and the pores by bacteria. It also reduces the appearance of papules and pustules which develop on the skin.

Isotretinoin is also known to change the characteristics of the sebum secreted by the skin. It also prevents the skin from hardening abnormally.

Directions for Use

Take it according to the dosage schedule prescribed by your consulting doctor. Tretiva 25 mg soft capsule is supposed to be taken orally and the patient should swallow it whole along with water. 

Do not puncture or try to chew the capsule. It is mostly recommended to take it with food however some formulations can be taken both with or without food. Taking it with food helps to increase the absorption of the drug isotretinoin into the bloodstream.

How Long Does It Take for a Tretiva Soft Capsule to Work?

Remission is seen in the acne if it is taken regularly for 20 weeks. A dosage of about 0.5 to 1 milligram per kg daily is given in most cases. The duration of the cores also depends on the intensity of the acne, age, and other health factors. If relapse of symptoms occurs then it can be treated in the same way although it is not normal.

What are the Dosage Instructions for Tretiva?

Creative Is taken around two times a day for up to 15 to 20 weeks. It can vary according to what your doctor has prescribed. Make sure that you do not skip your medication or stop taking it if you start feeling better. Interrupting the medicine treatment sooner than what has been recommended will close relapse of symptoms and your symptoms may become even worse.

Overdose

Overdosing symptoms include headache, nausea, abdominal discomfort. In case you develop any of these symptoms, you must contact your doctor immediately.

Missed Dose

In case you skip a dose, take the next dose as soon as you remember it; however if the time for the next door is already near then forget about the dose that you missed and start following the original routine. 

Do not double the dose or overdose the medicine to make up for the dose that has been missed by you as it will make it harder and good and it may lead to the development of harmful symptoms that occur due to overdosing. 

Sub Products of Tretiva Soft Capsule

Tretiva 5 Mg Capsule

It is the lowest concentration available of this medicine.

Tretiva 10 Mg Capsule

When starting isotretinoin treatment it is advisable to start it with a low dose.

Tretiva 20 Mg Capsule

It is the dosage prescribed if a 10 mg dose is not able to give satisfactory results.

Tretiva 30 Mg Capsule

It is another higher concentration of the same medicine.

Tretiva 40 Mg Capsule

It is a very high dose that is given to patients who have not responded to any of the above smaller doses. Take it with great caution only after being prescribed by a doctor since overdosing can be very harmful.

Mechanism of Action

The primary effect of isotretinoin is a reduction in the production of sebum. The secondary effect is the reduction in skin bacteria. It corrects abnormal keratinization of follicles and causes a great improvement in skin quality and in presenting Symptoms of acne. It is not accumulated in the body like many other retinoids are.

Adverse Side Effects

• Changes in skin color are observed
• Bleeding from nose
• Conjunctivitis
• There can be Scaling, burning, redness, and swelling of the skin
• Epistaxis
• Burning, dry and itchy eyes
• Itchy and dry skin
• Cheilitis
• Bleeding or swollen gums
• Increase in lipid enzymes
• Changes in the nail color
• Crusting of skin
• Hair loss and hair thinning
• Excessive Sweating
• Abdominal pain
• Bloody stools
• Ringing or buzzing in the ears
• Increase in serum lipid levels.
• Increase in liver enzymes
• Flu-like symptoms
• Increase in heart rate
• Fractures
• Intracranial tension
• Associated musculoskeletal symptoms
• Paronychia
• Pruritus

Warnings and Precautions

1. Do not donate blood while taking this medicine and up to one month after it. 
2. Protect your skin from too much sun exposure by using sunscreen or by wearing a protective covering.
3. Inform your doctor if your side effects do not go away. 
4. Inform your doctor if you develop stomach pain and nausea as it may indicate pancreatitis.
5. Drink plenty of water and use moisturizers to reduce the dryness of the skin.

Who Should Not Take It?

• Patients with intracranial hypertension should not use this medication.
• Do not use it if you have hypervitaminosis, that is, an increased amount of vitamin A in your body.
• Patients who are allergic to isotretinoin or other forms of vitamin A should also not use this medicine.
• Women who are pregnant or are planning to become pregnant during Tretiva treatment should not use this medicine at all.
• Patients with liver diseases should not use this medicine.
• Patients with a history of psychiatric disorders like anxiety, depression, mood swings should also not use this medicine.
• If you have a history of diabetes or hyperlipidemia in your family he should not use this medicine.
• Patients having osteoporosis should also not use this medicine as it can worsen this condition.

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FAQs

Is it safe to use a Tretiva capsule during pregnancy?

No, it is not safe to take Tretizen during pregnancy. Isotretinoin is a highly teratogenic drug. Up to 25% of the fetuses who have been exposed to it have had birth defects. The defects can be as serious as craniofacial abnormalities, heart abnormalities, and central nervous system abnormality.

Is it safe to use Tretiva while breastfeeding?

Isotretinoin is not safe to use while breastfeeding as similar drugs can pass through breast milk. 

Is it safe to use Tretiva for patients with liver disorders?

No, it is not safe to be used by patients with liver diseases. Isotretinoin can further worsen liver problems.

Is it safe to drive after taking Tretiva?

Do not drive after taking this medicine especially after dark as it sometimes affects the vision. Also, considering your safety, you should not operate any heavy machinery after taking isotretinoin.

Is it safe to use Tretiva for kidney disorders?

No harmful effects have ever been reported. However, inform your doctor about any such conditions before you start this treatment.

Can I take alcohol while taking this medicine?

No, do not take alcohol along with isotretinoin as it may increase the chances of developing problems like pancreatitis.

Tretiva Soft Capsule Alternatives

• Modern 10mg Soft Gelatin Capsule
• Matron 10mg Soft Gelatin Capsule
• Akena 10 Softgel Capsule
• Open 10mg Soft Gelatin Capsule
• Zeitoun 10 Soft Gelatin Capsules
• Cinestar 20 MG Capsule
• Acno 20 MG Capsule
• Isobel 20 MG Capsule
• Isotroin 20 MG Capsule
• I DERIVA 20 mg CAPSULE
• Accutane
• Tazorac

Conclusion

Thus, isotretinoin is a popular drug of choice used to treat severe, unresponsive acne. A large number of patients who have undergone isotretinoin therapy have reported satisfactory improvement in their symptoms after the treatment was completed. 

Several other conditions can also be treated using it, this includes some skin cancers, oral leukoplakia, actinic keratosis, and some other premalignant lesions. In these cases, the benefit and risk ratio for the treatment is not clear. You can avail this medication easily after you have a doctor’s prescription.