About Seroflo Inhaler 125 mcg

Seroflo inhaler 125 mcg is used to treat patients with asthma and COPD (chronic obstructive pulmonary disease). These diseases are associated with symptoms like wheezing, shortness of breath, and blockage of the respiratory path.

This glucocorticoid and beta two agonist combination clears respiratory pathways (bronchodilation) to facilitate breathing. It reduces the swelling in the airways, helps the patient to breathe easily.

Seroflo is a non-prescription inhaler and is available as an over-the-counter medication. However, always consult the medical professional personnel before taking the medication as the dosages have to be adjusted according to the severity of the disease or concerning allergies, diseases, or other medical conditions which vary from person to person.

Seroflo Inhaler 125 mcg Composition

Seroflo is a combination of adrenergic drug salmeterol and inhaled corticosteroids fluticasone.

Fluticasone propionate has high potency, longer duration, and negligible oral bioavailability. It is an inhaled glucocorticoid and suppresses inflammatory response.

Salmeterol is used for maintenance therapy and nocturnal asthma but not for acute symptoms. It is an adrenergic drug and causes bronchodilation.

Manufacturer of Seroflo Inhaler 125 mcg

Seroflo inhaler is manufactured by an Indian multinational pharmaceutical company Cipla limited. It is headquartered in Mumbai, India. It was founded in 1935. They strive to provide the most advanced medicines manufactured with the best of resources to everyone all across the globe.

Uses of Seroflo Inhaler 125 mcg

Prevents acute asthma episodes.

It is the mainstay of treatment of reversible nasal obstruction.

Prevents flare-ups or worsening of chronic pulmonary obstructive disease.

Prevents chronic bronchitis and emphysema.

Treats breathing difficulty, shortness of breath, coughing, wheezing, chest tightness caused by asthma or chronic pulmonary obstructive disease.

Improves pulmonary function.

Reduces swelling in Airways.

Acts as a bronchodilator by relaxing muscles of Airways.

Reduces sneezing runny nose and sinus discomfort.

Reduce breathlessness by preventing expiratory closure of peripheral airways and by abolishing the reversible component of airway obstruction.

How Does Seroflo Inhaler 125 mcg Work?

Salmeterol is a long-acting selective beta 2 agonist with a slow onset of action. It mainly acts as a bronchodilator. Increased cAMP inflammatory cells decrease mediator release. It reduces inflammatory reactions in the nose and other inflammatory cytokine releases.

It increases peak respiratory flow, reduces the need for rescue beta 2 agonist inhalation. Fluticasone has higher topical and low systemic availability.

How to Take Seroflo Inhaler 125 mcg?

Seroflo 125 is for inhalation only. To maintain a constant drug concentration, take it regularly at the same time every day. Shake the inhaler well, hold it in the mouth, and press down the inhaler once. Hold your breath for a few seconds.

You should repeat this as many times as directed by the medical professional. Rinse your mouth after use to prevent symptomatic or asymptomatic candidiasis. As rinsing removes the drug deposited in the mouth.

Dosage

It is usually used twice a day, twelve hours apart in the morning and evening. Use it at the same time every day. Consult the medical professional personnel before changing the dosage.

In case of overdose, call the doctor immediately if the patient has collapsed and you are unable to awaken him or her. Symptoms may include dizziness, blurred vision, chest pain, seizures, heart-pounding or irregular heartbeat, muscle cramp or weakness, dry throat, excessive tiredness, lack of energy, difficulty in sleeping or in staying asleep,  fainting, nausea, headaches, and uncontrolled shaking of body parts.

What If a Dose is Skipped?

In case a dose is skipped, take the next dose on time. Do not take a double dose to compensate for the dosage that has been missed. It can have more adverse effects.

Side Effects

Normal

• Hoarseness of voice
• Sleep problems
• Dyspnea
• Sore throat
• Asymptomatic and symptomatic oropharyngeal Candidiasis
• Vomiting
• Diarrhoea
• Stomach pain
• Irregular heartbeat
• Sneezing
• Muscle and bone pain
• Sweating
• Tooth pain
• Runny nose
• Nasopharyngitis
• Sinus pain and headache
• Serious
• Mood change
• Osteoporosis
• Growth retardation in children
• Early cataract
• Bruising
• Petechiae
• Pituitary -adrenal suppression
• Adrenal crisis in children during the stress of disease.
• Hypoglycemia
• White patches in the mouth
• Swallowing difficulty or choking
• Noisy and high pitched breathing
• Fainting
• Chills, fever, and other signs of infections

The concern of asthma worsening due to regular use of inhaled beta 2 agonist.

Drug Interaction of Seroflo Inhaler 125 mcg

Inform the doctor about all your ongoing medication and herbal medicines that you may be taking because many of them can react adversely with fluticasone and salmeterol.

Antibiotics like clarithromycin and chloramphenicol can cause overdose symptoms as they may increase the level of seroflo components salmeterol and fluticasone in the body.

Antifungals like voriconazole and itraconazole can also cause overdose symptoms in the body.

HIV drugs like atazanavir, ritonavir, and depression drugs like clomipramine, nefazodone can cause overdose symptoms in the body and prolong QT interval and other heart rhythm problems.

Increased blood pressure and heart drugs like acebutolol, atenolol, betaxolol, bisoprolol, esmolol, metoprolol, nadolol can cause worsening of asthma symptoms because they can block the action of seroflo inhaler components and cause the vessels of the lungs to constrict or tighten.

Diuretics like furosemide, torsemide, metolazone, hydrochlorothiazide can reduce potassium levels in the body leading to muscle cramps and put you at risk of low potassium levels.

However, interactions vary from person to person and you should always consult your doctor.

Special Warnings

Overdose can cause systemic effects due to absorption from the lungs.

Seroflo inhalers should be used cautiously in hypertensive patients, ischemic heart disease patients,s and those receiving digitalis.

Regular use of prolonged beta 2 agonists causes concern of asthma worsening and can even be life-threatening.

Discuss your allergies with your doctor

Skin rash

Hives

Swelling of  the face, mouth, feet, hands, and tongue

Problems related to breathing.

Don’t take this drug a second time if you have ever had an allergic reaction to it. Taking it again can cause death.

Discuss the history of osteoporosis, increased pressure, diabetes, hyperthyroidism, tuberculosis, glaucoma, or herpes with your doctor if someone in your family is suffering from the aforementioned diseases.

People suffering from liver disorders should inform their doctor about the same since this drug experiences first pass in the liver. A malfunctioning liver can cause increased levels of drugs in the body leading to symptoms of overdose.

Stay away from people with diseases like measles and chickenpox or other infectious diseases because this medication affects the immunity of the person.

Inform your surgeon including your dental surgeon about your medication if you are undergoing surgery.

If you are pregnant or breastfeeding a lady, you must take permission from a doctor before taking it. Inhaled steroids are however safe during pregnancy.

Avoid triggers like smoking, pollen, pollution, or others.

How to Store?

Store it away from sunlight, excess heat, and humidity (not in the bathroom). You can keep it at room temperature or below 25 degrees Celsius. Always, keep it out of reach from children and pets as most packaging is not child safe and can be opened by them easily.

Seroflo Inhaler 125 mcg Review

This drug is commonly used to treat asthma and chronic pulmonary obstructive disease. It is not a rescue medication, it is a maintenance medication.

It will not work in case of an asthma attack because it is not fast enough or in cases of status asthmaticus. The effects are noticeable and maximum after a week only.